COURSE INTRODUCTION AND APPLICATION INFORMATION


Course Name
Scientific Basis of Medicine IV
Code
Semester
Theory
(hour/week)
Application/Lab
(hour/week)
Local Credits
ECTS
SBM 202
Spring
16
4
18
18
Prerequisites
None
Course Language
English
Course Type
Required
Course Level
First Cycle
Mode of Delivery -
Teaching Methods and Techniques of the Course
Course Coordinator
Course Lecturer(s)
Assistant(s)
Course Objectives This course aims to cover: • Basic principles of pharmacology including pharmacodynamics and pharmacokinetics • Basic concepts of infection, infection control, pathogenesis and microbiology of medically important microorganisms • Molecular and cellular components and pathways of innate and adaptive immune responses that protect an organism from infections or cancer. • General mechanisms of disease including cellular adaptation and injury, inflammation, intracellular accumulations, tissue repair and regeneration, hemodynamic disorders and thrombosis, shock, immune disorders and cancer • Basic principles of epidemiology • Basic principles of imaging and clinical laboratory methods and their clinical applications. • Changing health needs and challenges along the human life cycle
Learning Outcomes The students who succeeded in this course;
  • 1. List the phases of drug development and explain their features, classify the drugs, define the drug and the body interaction and the factors altering this interaction
  • 2. Explain the major determinants of infectious diseases, the links in the “chain of infection” and the role of correct diagnosis, treatment and appropriate infection control measures for breaking the links
  • 3. Define the main microbiological features of medically important pathogens
  • 4. Explain molecular and cellular components and pathways of innate and adaptive immune responses that protect an organism from infections or cancer
  • 5. Explain the causes and mechanisms of reversible and irreversible cell injury
  • 6. Explain the mechanisms of inflammation, define its types and associated morphologic features
  • 7. Define the mechanisms of tissue repair, explain the factors influencing the tissue repair, define the differences between primary and secondary wound healing
  • 8. Explain the mechanisms of hemodynamic disorders, thrombus, embolism and infarction and define their morphological features
  • 9. List the shock types and explain their pathogenesis, morphological and clinical features
  • 10. Explain the basic processes underlying the transformation of a normal cell to its malignant counterpart, and the consequences of malignant transformation on the cellular and organism level.
  • 11. Define the basic nomenclature, morphologic characteristics, grading and staging of tumors, and the principles of tumor diagnosis and treatment.
  • 12. Define the basic principles of imaging and clinical laboratory methods and their clinical applications.
  • 13. Define the characteristics of different stages of healthy life from childhood to the end-of-life, the lifecycle related health risks and preventive measures.
  • 14. Explain how the basic concepts in epidemiology and biostatistics are applied to causal factors for health problems.
Course Description In this course; relevant topics in general pharmacology, medical microbiology and immunology, basic pathology and epidemiology will be covered. This course intends to lay a foundation for year 3, in where diseases of organ systems, their diagnosis and treatments will be discussed.
Related Sustainable Development Goals

 



Course Category

Core Courses
X
Major Area Courses
Supportive Courses
Media and Managment Skills Courses
Transferable Skill Courses

 

WEEKLY SUBJECTS AND RELATED PREPARATION STUDIES

Week Subjects Required Materials
1 Pharmacology, Infection Basics, Intoduction to Immune response Lecture notes and references
2 Basic concepts in bacteriology, innate Immunity Lecture notes and references
3 Molecular basis of adaptive immunity Lecture notes and references
4 Bacteriology, Adaptive immunity Lecture notes and references
5 Mycology, Epidemiology, Humoral Immunity Lecture notes and references
6 Virology , Lecture notes and references
7 Bacteriology, Parasitology Epidemiology Lecture notes and references
8 Pathology, bacteriology Lecture notes and references.
9 Pathology, Lecture notes and references.
10 Virology Lecture notes and references.
11 Pathology Lecture notes and references.
12 Parasitology Lecture notes and references.
13 Study Week No lectures.
14 Immunology Lecture notes and references.
15 RAMADAN HOLIDAY -
16 Molecular mechanisms of cancer Lecture notes and references.
17 Pathology- cancer Lecture notes and references
18 Life-cycle Lecture notes and references
Course Notes/Textbooks
  1. 1. Basic and Clinical Pharmacology, McGraw-Hill Medical, 13th Edition.

    https://accessmedicine.mhmedical.com/book.aspx?bookid=2249

    2. Goodman & Gilman’s Pharmacological Basis of Therapeutics, McGraw-Hill Medical 13th Edition, Chapter 52.

    https://accessmedicine.mhmedical.com/content.aspx?bookid=2189&sectionid=172483986#1149954192

    3. Katzung & Trevor's Pharmacology: Examination & Board Review, 11th Edition

    https://accessmedicine.mhmedical.com/book.aspx?bookid=1568

    4. Thomson & Thomson Genetics in Medicine, 8th Edition, Elsevier

    5. Molecular Biology of the Cell

    6. Molecular Biology of Cancer, 4th Edition

    7. Robbins Basic Pathology, 9th Edition

    8. Robbins and Cotran Pathologic Basis of Disease, Student Consult, 9th Edition

    9. Pathology: The Big Picture, Lange.

    https://accessmedicine.mhmedical.com/book.aspx?bookid=499

    10. Pathophysiology of Disease: An Introduction to Clinical Medicine, 8 th edition

    11. Clinical Biochemistry, An Illustrated Colour Text

    12. Harper’s Illustrated Biochemistry, 30th Ed.

    13. Review of Medical Microbiology & Immunology: A Guide to Clinical Infectious Diseases, 15 th edition https://accessmedicine.mhmedical.com/book.aspx?bookID=2381

    14. Sherris Medical Microbiology 7th edition

    https://accessmedicine.mhmedical.com/book.aspx?bookID=2268

    15. Jawetz, Melnick, & Adelberg’s Medical Microbiology, 27 th edition https://accessmedicine.mhmedical.com/book.aspx?bookID=1551

    16. Lecture Notes: Epidemiology, Evidence-based Medicine and Public Health, 6th edition.

    17. HumanPhysiology / Development:birththroughdeath. http://en.wikibooks.org/wiki/Human_Physiology/Development:_birth_through_death%23Adulthood.

    18. Disease Prevention & Health Promotion. Current Medical Diagnosis & Treatment. 56th ed. McGraw-Hill Education; Chp.1.

    https://accessmedicine.mhmedical.com/book.aspx?bookID=2449

    19. The year in cardiology 2018: prevention. European Heart Journal (2019) 40, 336–344. doi:10.1093/eurheartj/ehy894

    20. WHO/ Noncommunicable diseases and their risk factors/ STEPwise approach to chronic disease risk factor surveillance/ Country Fact Sheets(https://www.who.int/ncds/surveillance/steps/Factsheet-STEPS-Turkey-ENG-08.10.2018.pdf?ua=1)

    21. Determinants of Health and Health Inequities. AFMC Primer on Population Health. (2nd edition)

    The Association of Faculties of Medicine of Canada, Ottawa,  p45-68 https://afmc.ca/AFMCPrimer.pdf?ver=1.2

    22. Human Sexuality from cells to society, Wadsworth Publishing

    23. Human Sexuality, Pearson

    24. Human Sexuality. 5th. Ed. Harper Collins College Publisher

Suggested Readings/Materials

 

EVALUATION SYSTEM

Semester Activities Number Weigthing
Participation
Laboratory / Application
Field Work
Quizzes / Studio Critiques
Portfolio
Homework / Assignments
1
10
Presentation / Jury
Project
Seminar / Workshop
Oral Exam
1
10
Midterm
3
45
Final Exam
1
35
Total

Weighting of Semester Activities on the Final Grade
65
Weighting of End-of-Semester Activities on the Final Grade
35
Total

ECTS / WORKLOAD TABLE

Semester Activities Number Duration (Hours) Workload
Course Hours
(Including exam week: 18 x total hours)
18
16
288
Laboratory / Application Hours
(Including exam week: 18 x total hours)
18
4
Study Hours Out of Class
18
2
36
Field Work
Quizzes / Studio Critiques
Portfolio
Homework / Assignments
1
10
Presentation / Jury
Project
Seminar / Workshop
Oral Exam
1
10
Midterms
3
10
Final Exams
1
28
    Total
474

 

COURSE LEARNING OUTCOMES AND PROGRAM QUALIFICATIONS RELATIONSHIP

#
Program Competencies/Outcomes
* Contribution Level
1
2
3
4
5
1

Explain the normal structure and functions of the human body at the molecular, cellular, tissue, organ and system levels, associate them with suggestions, practices and clinical situations (nutrition, exercise, vaccination, mental health, etc.); to protect and improve the health of individuals.

X
2

Describe the mechanisms of diseases at the molecular, cellular, tissue, organ and system levels and make evidence-based decisions by associating them with disease findings, diagnosis and treatment approaches.

X
3

Consider the ethical principles, scientific facts, legal regulations and the biopsychosocial and cultural characteristics of the patient in the medical decision making process. Place importance and respect the autonomy of patients and the confidentiality of patient information, within the framework of the law and the provisions of healthcare application standards.

X
4

Prioritize patient safety to minimize malpractice by carrying out risk assessment, take the necessary precautions, perform the necessary medical practice and record them.

X
5

Communicate healthily, openly and effectively with healthcare workers, patients and their relatives, with the communication structured on empathy and care, trust and constructiveness; while being respectful to language, belief, race and cultural characteristics.

X
6

By bearing in mind the patients’ values, beliefs, priorities, and needs; provide evidence-based options and include them in the decision making process.

X
7

Preserve our planet’s resources and consider its effects on the public and individual’s health, advocate to disseminate healthy lifestyle behaviors and modify factors that affect health adversely.

X
8

Reach current, valid and reliable information effectively using technology. Critically evaluate this information for solving problems in an evidence-based medical decision-making process, bearing in mind prevention, diagnosis, and management of diseases.

9

Identify problems, create hypotheses, conduct research and employ teamwork to analyze results for generation and dissemination of health-related scientific knowledge.

10

By taking feedback and evaluating their performance, determine the areas and options for improvement and implement them within a plan.

11

Care for their own personal health, safety and appearance, take the necessary precautions in order to set an example for their colleagues and society.

12

Continuously renew themselves in their medical knowledge by always bearing in mind their commitment to lifelong learning principles.

X
13

Using various communication tools, share their professionally gained knowledge in the field of healthcare, opinions, experiences, and evaluations with institutions, colleagues and the public.  Advocate for healthcare and contribute to developing policies to protect and improve it.

*1 Lowest, 2 Low, 3 Average, 4 High, 5 Highest